The Chair of Biomedicine and Neuroscience aims to give students a grounding in quantitative approaches to solving biological problems, as well as to develop their own vision of modern biological problems and ways to cope with them. Our balanced academic program is designed to train students who have earned Bachelor Degrees in a variety of fields such as biology, physics, mathematics or chemistry. The main result of our scientific and educational program is to achieve for students a high level of their independent research. Students direct partly participate in research from the first year of study (up to 50% of the time), and during the second year they work almost exclusively on their diploma projects in the research groups of our laboratories. All motivated students in the first year are employed and involved in international projects. Upon obtaining their Master Degrees, they have the priority right to enter the Ph. D. program at Kyiv Academic University. During the implementation of research projects, students interact with scientists from leading laboratories in Europe and the United States. The students are trained to use the state-of-the-art scientific equipment located in our laboratories recently obtained for fulfillment of international and domestic projects.

Research at the Chair is conducted in the following departments of Bogomoletz Institute of Physiology:

Molecular Biophysics

In our work, we try to understand how individual neurons and small neural networks function in the brain structure under normal and pathological conditions. The main research areas of the Department of Molecular Biophysics include signaling of Neuronal Calcium Sensory proteins, inhibitory synaptic receptor functioning and peripheral and central mechanisms of neuropathic pain. Our research involves isolated and cultured neurons as well as the brain slices and intact spinal cord preparation. The following modern experimental methods are used in our research: optical (digital and confocal microscopy), electrophysiological (microelectrodes, iontophoresis, patch clamp), genetic (transfection, infection, site-specific mutagenesis) and mathematical (mathematical modeling, mathematical statistics).

The department conducts joint research and has common grants with many domestic and foreign laboratories. Our partners are:

Our projects are supported by the following grants :

  • Studies of genetically-determined molecular mechanisms of inter- and intracellular signaling in normal and pathological conditions. NASU (# ІІ - 1- 12) - 01/01/2017–12/31/2022
  • Pan-European twinning to re-establish world-level Neuroscience Centre in Kiev (NEUROTWIN). Horizon 2020 Framework Programme (857562 — NEUROTWIN) - 01/08/2019 – 31/07/2022
  • The Role of the Complement System in Spinal Mechanisms of Chronic Pain. The National Institutes of Health of USA (1R01NS113189-01) - 06/15/2019 – 05/31/2024
  • Effective treatment of peripheral nerve injury by biomimetic 3D scaffolds. National Research Foundation of Ukraine (2021.01/0328) 01/03/2022 – 15/12/2024

Molecular pathophysiology

Our main scientific interest is to understand the molecular mechanisms of diseases, especially cardiovascular ones. We use experimental systems of different levels - from isolated organelles to the whole organism, and a wide range of methods: recording cardiohemodynamics, biochemical reactions, immunofluorescence and electron microscopy, RNA interference, qPCR, single-cell RT-PCR and many others. We use these approaches to understand cardiovascular pathology and develop new therapies to treat diseases. Additionally, functional, genetic, sport population studies as well as pharmacogenetic research are conducted. We use modern methods of data analysis (MDR, random forest and others) to obtain more valuable results from our experimental data. Our friendly team is open for cooperation!

Sensory Signaling

The Department studies the molecular mechanisms of acute and chronic pain. The main goal of our research is to better understand the functioning of nociceptive (pain processing) neurons of the dorsal ganglia and dorsal horn of the spinal cord in different models of neuropathic and inflammatory pain. Understanding the functioning of calcium-regulating systems and ion channels in these neurons is extremely important for developing new approaches in the treatment of pain of various origins. The department uses the latest equipment for simultaneous measurement of intracellular concentration of calcium ions and transmembrane currents, as well as methods for animal behavioral testing. This allows us to study the casual links between changes in molecular mechanisms at the cellular level with certain disorders of sensory sensitivity of animals at the level of whole animals.

The department conducts joint research and has common grants with many domestic and foreign laboratories. Our partners are:

Our projects are supported by the following grants :

  • Studies of genetically-determined molecular mechanisms of inter- and intracellular signaling in normal and pathological conditions. NASU (# ІІ - 1- 12) - 01/01/2017–12/31/2022
  • Pan-European twinning to re-establish world-level Neuroscience Centre in Kiev (NEUROTWIN). Horizon 2020 Framework Programme (857562 — NEUROTWIN) - 01/08/2019 – 31/07/2022
  • The Role of the Complement System in Spinal Mechanisms of Chronic Pain. The National Institutes of Health of USA (1R01NS113189-01) - 06/15/2019 – 05/31/2024
  • Effective treatment of peripheral nerve injury by biomimetic 3D scaffolds. National Research Foundation of Ukraine (2021.01/0328) 01/03/2022 – 15/12/2024