The Department of Biophysics and Molecular Physiology is a joint department of KAU and the Bogomoletz Institute of Physiology National Academy of Sciences of Ukraine. The department is focused on master students and philosophy doctors reserch-intensive education programs on contemporary areas of fundamental biophysics, molecular physiology and neurophysiology.
The main areas of research are:
1. biophysical properties of ion channels of cell membranes;
2. heterogeneous expression of ion channels;
3. the mechanisms of regulation of intracellular Ca2+ concentration and calcium signaling in different cell types;
4. thr molecular mechanisms of synaptic transmission;
5. research of properties of stem cells;
6. study of polymorphisms of genes;
7. molecular and cellular mechanisms of pain and neurodegenerative diseases;
The following experimental methods are used in the studies: optical (digital, phase-contrast and confocal microscopy), electrophysiological (fixation of potentials and currents by microelectrodes and in the form of a pectin-clamp, ionophoresis), genetic (transfection, infection, site-specific mutagenesis, analysis DNA using PCR), immunohistochemical (using fluorescent confocal microscopy) and mathematical (mathematical modeling and programming, mathematical statistics). The experiments use freshly-isolated cells (neurons, endocrine cells, smooth muscle cells, cardiomyocytes) or cell culture, as well as brain and intact brain cuts.
The department has a collaboration with University College of London (London, UK), University of Iowa (Iowa City, USA), École Polytechnique CNRS (Paris, France), Johns Hopkins University (Baltimore, USA), University of Liverpool (Liverpool, UK) , Institute for Molecular and Cell Biology (Porto, Portugal), University of Lille (Lille, France).